Oxidative stress plays a crucial role in the development of complications associated with diabetes, particularly when it comes to the health of the heart and blood vessels. This oxidative stress disrupts the metabolism of individuals with diabetes, leading to excessive production of mitochondrial superoxide in the endothelial cells found in both large and small blood vessels. The end results. Impaired diastole, which is a critical aspect of heart function. One of the primary pathological changes seen in individuals with diabetes is a dysfunction in the ability of blood vessels to dilate, a condition known as vasodilation dysfunction. This malfunction is the foundation for various diabetic vascular complications, including atherosclerosis and other cardiovascular diseases. Numerous studies have suggested a potential solution to this problem: pomegranate flower polyphenols (PFP) extract.

PFP extract has shown promise as a potent antioxidant that can lower blood sugar levels and combat inflammation. Moreover, it has demonstrated the ability to enhance vasodilation in the endothelial cells of diabetic rats. This is achieved by inhibiting the production of endothelial-derived contracting factors such as endothelin-1, angiotensin II, and thromboxane B2 while simultaneously increasing the concentration of 6-keto-PGF1a in the bloodstream. In this context, our aim is to highlight how PFP antioxidants can effectively counteract the detrimental effects of oxidative stress and significantly improve diastolic relaxation in rats with hyperglycemia. In essence, besides their role in diabetes treatment, antioxidants hold the potential for numerous therapeutic benefits by mitigating the negative impact of oxidative stress on the body.

Auckland, New Zealand | MMC Reg. No. 74494; ORCID: https://orcid.org/0000-0003-3831-2459

Scopus Author ID: 57201420645; Web of Science ResearcherID: AAN-4913-2020

·    More than 23 years’ experience in health education and healthcare service overseas.

·    Certificate of New Zealand International Qualification Assessment (IQA).

·    High-End Foreign Experts-China.

·    High-End Foreign Experts-Malaysia.

·    Malaysian APC (Annual Practicing Certificate) and teaching permit.

·    Residence Pass-Talent (RP-T) in Malaysia.

·    Chosen for Who’s Who in Medicine and Healthcare 2009/2010.

·    Overseas full practicing certificate to practice and teach medicine.

·    Have published over 50 research papers in SCI Journals and written a book on diabetes.

Career

·    Senior Research Fellow and Foreign Expert, Medical College, AUST University, China.          

·    Honorary Professor and External Advisor from New Zealand, Widad University College, Malaysia        

·    Visiting Professor and Academic Advisor, Xi'an Jiaotong-Liverpool University (XJTLU) and UNESCO CHAIR Conjoined program                  

·    Associate Professor and High-end Foreign Expert, College of Medicine, Chengdu University, China.  

·    High-end Foreign Expert and faculty member, Medical College, SEGi University, Malaysia.                                                            

·    High-end Foreign Expert and faculty member, Medical College, Asia Metropolitan University, Malaysia.                                   

Research

·      Experienced and passionate about basic and clinical research, research has been focused on genetic susceptibility to allergic/autoimmune related diseases, as well as acupuncture, holistic, and botanical medicine research.