| Biography | |
|---|---|
 Dr. Nadeem A. Ansari Khwaja Moinuddin Chishti Language University, India |
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| Title: Role of Enzymes of HMP-Shunt in Type2 Diabetes Mellitus | |
| Abstract: Glucose 6 phosphate dehydrogenase (G6PD) & 6-Phosphogluconolactone Dehydrogenase (6PGD), enzymes of HMP-Shunt (HMPS) or Pentose Phosphate Pathway (PPP), are present in the cytoplasm of many cells including red blood cells that produced NADPH. NADPH act as antioxidant via reduction of Glutathione and used to detoxify high level of reactive oxygen species produced during rapid cell multiplication thereby promoting cell survival. HMPS is the only pathway which use glucose to produce ribose 5 phosphate and provide raw material for nucleic acid and it also protect and stabilize DNA which makes cancer cells more resistance to chemotherapy. Hyperglycemia &/or aberrant post-translational modification induced highly glycated G6PD or 6PGD decrease its activity leading to absence of NADPH production & thus inactiveness of Glutathione antioxidant system causing diabetic complications. Recent studies have shown that the down regulation of transketolase activity in type 2 DM. Inborn defeciency or down-regulation or non-functionality of these enzymes might be linked with decreased risk of cancer & metabolic diseases. Keywords:-- G6PD, 6PGD, HMP Shunt, NADPH, Diabetes mellitus, Glutathione, glycated | |
